どなたでも論文ゼミに参加可能ですので、参加を希望される方は小笠原までご連絡ください。
<2024年>
12月18日：小笠原
Longitudinal humoral analysis in RSV-infected infants identifies pre-existing RSV strain-specific G and evolving cross-reactive F antibodies
Nadege Nziza, et al.,
Immunity, 2024 PMID: 38876099
12月4日：吉田(圭）
Stability of influenza A virus in droplets and aerosols is heightened by the presence of commensal respiratory bacteria.
David SC, Schaub A, Terrettaz C, Motos G, Costa LJ, Nolan DS, Augugliaro M, Wynn HK, Glas I, Pohl MO, Klein LK, Luo B, Bluvshtein N, Violaki K, Hugentobler W, Krieger UK, Peter T, Stertz S, Nenes A, Kohn T.
J Virol. 2024 98(7):e0040924. PMID: 38869284
12月4日：山本
The actin-binding protein palladin associates with the respiratory syncytial virus matrix protein.
Shadi Shahriari et al.,
JVI, 2024 PMID 39360826
11月27日：永島
The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity
Grumov D, Kostarnoy A, Gancheva P, Kondratev A.
Nat Com. 2024. PMID: 39333588.
11月13日：高柳
Cholesterol-rich lysosomes induced by respiratory syncytial virus promote viral replication by blocking autophagy flux
Lifeng Chen et al.
Nat Com, 2024 PMID 39060258
10月17日：白石
A Simple and Rapid Microscale Method for Isolating Bacterial Lipopolysaccharides.
Grumov D, Kostarnoy A, Gancheva P, Kondratev A.
Int J Mol Sci. 2024. 25,6345.
9月19日：西巻
Severe Morbidity and Short- and Mid- to Long-term Mortality in Older Adults Hospitalized with Respiratory Syncytial Virus Infection。
Hung Fu Tseng, Lina S Sy, Bradley Ackerson, Zendi Solano, Jeff Slezak, Yi Luo, Christine A Fischetti, Vivek Shinde
J Infect Dis. 2020.
9月5日：横田
Lassa virus Z protein hijacks the autophagy machinery for efficient transportation by interrupting CCT2-mediated cytoskeleton network formation.
Yuan Y, Fang A, Zhang M, Zhou M, Fu ZF, Zhao L.
Autophagy. 2024 Jul 20:1-18. doi: 10.1080/15548627.2024.2379099. PMID: 39007910
8月29日：吉田(圭)
Frequency, kinetics and determinants of viable SARS-CoV-2 in bioaerosols from ambulatory COVID-19 patients infected with the Beta, Delta or Omicron variants.
Jaumdally S, Tomasicchio M, Pooran A, Esmail A, Kotze A, Meier S, Wilson L, Oelofse S, van der Merwe C, Roomaney A, Davids M, Suliman T, Joseph R, Perumal T, Scott A, Shaw M, Preiser W, Williamson C, Goga A, Mayne E, Gray G, Moore P, Sigal A, Limberis J, Metcalfe J, Dheda K.
Nat Commun. 2024. 15(1):2003. PMID: 38443359
8月22日：山本
Deviations in RSV epidemiological patterns and population structures in the United States following the COVID-19 pandemic.
Rios-Guzman E, Simons LM, Dean TJ, Agnes F, Pawlowski A, Alisoltanidehkordi A, Nam HH, Ison MG, Ozer EA, Lorenzo-Redondo R, Hultquist JF.
Nat Commun. 2024. 15(1):3374. PMID: 38643200
8月1日：吉田(有)
A universal recombinant adenovirus type 5 vector-based COVID-19 vaccine.
Li X, Peng Q, Liu X, Xu H, Liu J, Wu X, Ye Q, Li M, Li Y.
Front Immunol. 2024. 15:1374486. PMID: 38745651
7月18日：吉田(圭)
Influenza virus uses mGluR2 as an endocytic receptor to enter cells.
Ni Z, Wang J, Yu X, Wang Y, Wang J, He X, Li C, Deng G, Shi J, Kong H, Jiang Y, Chen P, Zeng X, Tian G, Chen H, Bu Z.
Nat Microbiol. 2024. 9(7):1764-1777. PMID: 38849624
7月11日：中村
Disinfectants in a Hemodialysis Setting: Antifungal Activity Against Aspergillus and Fusarium Planktonic and Biofilm Cells and the Effect of Commercial Peracetic Acid Residual in Mice.
Lopes LG, Csonka LA, Castellane JAS, Oliveira AW, de Almeida-Júnior S, Furtado RA, Tararam C, Levy LO, Crivellenti LZ, Moretti ML, Giannini MJSM, Pires RH.
Front Cell Infect Microbiol. 2021. 11:663741. PMID: 33996634
7月4日：西巻
Natto extract inhibits infection caused by the Aujeszky's disease virus in mice.
Kobayashi J et al.
Microbiol Immunol. 2023. 67(12):514-519. PMID: 37815203
6月13日：白石
Wall teichoic acid substitution with glucose governs phage susceptibility of Staphylococcus epidermidis.
Beck C, Krusche J, Notaro A, Walter A, Kränkel L, Vollert A, Stemmler R, Wittmann J, Schaller M, Slavetinsky C, Mayer C, De Castro C, Peschel A.
mBio. 2024. 15(4):e0199023. PMID: 38470054
6月6日：吉田(有)
Engineered dityrosine-bonding of the RSV prefusion F protein imparts stability and potency advantages
Sonal V Gidwani, et al.
Nat Commun. 2024. 15(1):2202. PMID: 38485927
5月30日：小笠原
Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens
Rüdiger Groß, et al.
Nat Microbiol. 2024 Apr;9(4):905-921.
doi: 10.1038/s41564-024-01637-6. Epub 2024 Mar 25. PMID: 38528146
5月16日：山本
Human Respiratory Syncytial Virus NS2 Protein Induces Autophagy by Modulating Beclin1 Protein Stabilization and ISGylation
Kim Chiok, Swechha M Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L Haas, Kim C Tran, Michael N Teng, Santanu Bose.
mBio. 2022. 13(1):e0352821. PMID: 35038909
4月25日：永島
Bifidobacterium Longum Promotes Postoperative Liver Function Recovery in Patients with Hepatocellular Carcinoma.
Yu, Jingjing, Peng Zhu, Linlin Shi, Na Gao, Yani Li, Chang Shu, Ying Xu, et al.
Cell Host Microbe. 2024. 32 (1): 131–144. PMID 38091982
4月18日：中村
Efficacy of combined disinfection with a nitric oxide donor in controlling biofilm formation on the reverse osmosis water pathway for hemodialysis
Yoshihiro Tange, Ayane Murata, Shigenori Yoshitake
J Water Health. 2023 Oct;21(10):1591-1599. PMID: 37902212
4月4日：白石
Crucial Role for Lipoteichoic Acid Assembly in the Metabolic Versatility and Antibiotic Resistance of Staphylococcus aureus.
Burtchett TA, Shook JC, Hesse LE, Delekta PC, Brzozowski RS, Nouri A, Calas AJ, Spanoudis CM, Eswara PJ, Hammer ND.
Infect Immun. 2023 91(7):e0055022. PMID:37347167
3月21日：吉田(圭)
Prevention of respiratory virus transmission by resident memory CD8+ T cells.
Uddbäck I, Michalets SE, Saha A, Mattingly C, Kost KN, Williams ME, Lawrence LA, Hicks SL, Lowen AC, Ahmed H, Thomsen AR, Russell CJ, Scharer CD, Boss JM, Koelle K, Antia R, Christensen JP, Kohlmeier JE.
Nature. 2024 626(7998):392-400. PMID: 38086420
3月14日：吉田(有)
Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents. Umemoto S, Nakahashi-Ouchida R, Yuki Y, Kurokawa S, Machita T, Uchida Y, Mori H, Yamanoue T, Shibata T, Sawada SI, Ishige K, Hirano T, Fujihashi K, Akiyoshi K, Kurashima Y, Tokuhara D, Ernst PB, Suzuki M, Kiyono H.
NPJ Vaccines. 2023 8(1):106. PMID: 37488116
3月7日：永島
Distinctive probiotic features share common TLR2-dependent signalling in intestinal epithelial cells.
Paveljšek D, Ivičak-Kocjan K, Treven P, Benčina M, Jerala R, Rogelj I.
Cell Microbiol. 2021 (1):e13264. PMID: 32945079
2月29日：山本
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
Sake SM et al.
Nat Commun. 2024 15(1):1173. PMID: 38332002
2月15日：中村
Five-year trends in bacterial contamination of dialysis equipment
Osono E, Honda K, Inoue Y, Ichimura K, Kamano C, Kawamoto S, Norose Y, Takaku S, Morita R, Tsuchido T.
J Microorg Control. 2023 28(3). PMID: 37866898
2月1日：白石
The absence of surface D-alanylation, localized on lipoteichoic acid, impacts the Clostridioides difficile way of life and antibiotic resistance Lacotte PA, Denis-Quanquin S, Chatonnat E, Le Bris J, Leparfait D, Lequeux T, Martin-Verstraete I, Candela T.
Front Microbiol. 2023 14:1267662. PMID: 37965542
1月18日：小笠原
Early human lung immune cell development and its role in epithelial cell fate
Josephine L Barnes et al.,
Sci Immunol. 2023 Dec 15;8(90):eadf9988. doi: 10.1126/sciimmunol.adf9988. PMID: 38100545
1月11日：横田
Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection.
Bagdonaite I, Marinova IN, Rudjord-Levann AM, Pallesen EMH, King-Smith SL, Karlsson R, Rømer TB, Chen YH, Miller RL, Olofsson S, Nordén R, Bergström T, Dabelsteen S, Wandall HH.
Nat Commun. 2023 Nov 2;14(1):7000. doi: 10.1038/s41467-023-42669-6. PMID: 37919266
<2023年>
12月21日：吉田(圭)
Imaging analysis reveals budding of filamentous human metapneumovirus virions and direct transfer of inclusion bodies through intercellular extensions.
El Najjar F, Castillo SR, Moncman CL, Wu CY, Isla E, Velez Ortega AC, Frolenkov GI, Cifuentes-Munoz N, Dutch RE.
mBio. 2023 14(5):e0158923. PMID: 37681946
12月14日：吉田(有)
Intranasal parainfluenza virus type 5 (PIV5)-vectored RSV vaccine is safe and immunogenic in healthy adults in a phase 1 clinical study.
Spearman P, Jin H, Knopp K, Xiao P, Gingerich MC, Kidd J, Singh K, Tellier M, Radziewicz H, Wu S, McGregor M, Freda B, Wang Z, John SP, Villinger FJ, He B.
Sci Adv. 2023 9(43):eadj7611. PMID: 37878713
11月30日：永島
Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling.
d'Hennezel E, Abubucker S, Murphy LO, Cullen TW.
mSystems. 2017 2(6):e00046-17. PMID: 29152585
11月16日：山本
Marie-Helene Corre et al., Bacterial matrix metalloproteases and serine proteases contribute to the extra-host inactivation of enteroviruses in lake water ISME J, 2022, PMID:35545659
11月2日：小笠原
Xu Qin et al., Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children
Nat Immunol. 2023, PMID:36536106
10月19日：谷向
Kleiner, V.A., O. Fischmann, T., Howe, J.A. et al.Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Commun Biol 6, 649 (2023).
9月21日：山本
Respiratory syncytial virus ribonucleoproteins hijack microtubule Rab11 dependent transport for intracellular trafficking
Gina Cosentino, Katherine Marougka, Aurore Desquesnes, Nicolas Welti, Delphine Sitterlin, Elyanne Gault, Marie-Anne Rameix-Welti
PLoS Pathog. 2022;18(7):e1010619. PMID: 35797399
9月14日：吉田
Licochalcone A plays dual antiviral roles by inhibiting RSV and protecting against host damage.
Li Z, Li B, Chen Z, Xu J, El Sabbagh A, Zhao Y, Du R, Rong L, Tian J, Cui Q.
J Med Virol. 2023 95(8):e29059. PMID: 37635463
9月7日：白石
Structure and Anti-Inflammation Potential of Lipoteichoic Acids Isolated from Lactobacillus Strains.
Lu Q, Guo Y, Yang G, Cui L, Wu Z, Zeng X, Pan D, Cai Z.
Foods. 2022 11(11):1610. PMID: 35681360
8月31日：中村
Safety and efficacy of the Seraph® 100 Microbind® Affinity Blood Filter to remove bacteria from the blood stream: results of the first in human study. Eden G st al., Crit Care., 2022; 26(1):181. doi: 10.1186/s13054-022-04044-7. PMID: 35715801
8月24日：永島
Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS.
Francisco A, et al., Front Immunol. 2022 Jan 24;12:748303. doi: 10.3389/fimmu.2021.748303. eCollection 2021.
PMID: 35140704
8月3日：白石
Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
Cancer Discov. 2017 7(5):522-538. PMID: 28202625.
7月27日：横田
Nei-like DNA glycosylase 2 (NEIL2) selectively antagonizes interferon-β expression upon respiratory syncytial virus infection.
Pan L, Xue Y, Wang K, Zheng X, Islam A, Tapryal N, Chakraborty A, Bacsi A, Ba X, Hazra TK, Boldogh I.
J Biol Chem. 2023 Jul 7:105028. doi: 10.1016/j.jbc.2023.105028. Online ahead of print. PMID: 37423306
7月20日:吉田
Pathophysiology of reinfection by exogenous HSV-1 is driven by heparanase dysfunction
Suryawanshi RK, Patil CD, Agelidis A, Koganti R, Yadavalli T, Ames JM, Borase H, Shukla D.
Sci Adv. 2023 9(17):eadf3977. PMID: 37115924
7月13日:谷向
Safety and Antiviral Effects of Nebulized PC786 in a Respiratory Syncytial Virus Challenge Study
DeVincenzo J, Cass L, Murray A, Woodward K, Meals E, Coates M, Daly L, Wheeler V, Mori J, Brindley C, Davis A, McCurdy M, Ito K, Murray B, Strong P, Rapeport G.
J Infect Dis. 2022 25(12):2087-2096. PMID: 33216113
7月6日:山本
CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection
B Vijayalakshmi Ayyar, Khalil Ettayebi, Wilhelm Salmen, Umesh C Karandikar, Frederick H Neill, Victoria R Tenge, Sue E Crawford, Erhard Bieberich, B V Venkataram Prasad, Robert L Atmar, Mary K Estes
Nat Commun 2023 Feb 28;14(1):1148. PMID: 36854760
6月22日:横田
Oligopeptide Transporters of Nonencapsulated Streptococcus pneumoniae Regulate CbpAC and PspA Expression and Reduce Complement-Mediated Clearance.
Thompson CD, Bradshaw JL, Miller WS, Vidal AGJ, Vidal JE, Rosch JW, McDaniel LS, Keller LE.
mBio. 2023;14(1):e0332522. doi: 10.1128/mbio.03325-22. PMID: 36625598
6月15日:永島
Oster, Paul, Laurie Vaillant, Erika Riva, Brynn McMillan, Christina Begka, Caroline Truntzer, Corentin Richard, et al. 2022. “Helicobacter Pylori Infection Has a Detrimental Impact on the Efficacy of Cancer Immunotherapies.” Gut 71 (3): 457–66.
PMID: 34253574
6月8日:谷向
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.
Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H.
Science. 2023 379(6632):586-591. PMID: 36758070.
6月1日:白石
Lipoteichoic Acid Inhibits Lipopolysaccharide-Induced TLR4 Signaling by Forming an Inactive TLR4/MD-2 Complex Dimer.
Watanabe S, Zenke K, Muroi M.
J Immunol. 2023. 210(9):1386-1395. PMID: 36897262
5月18日:吉田
An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2.
Barnett KC, Xie Y, Asakura T, Song D, Liang K, Taft-Benz SA, Guo H, Yang S, Okuda K, Gilmore RC, Loome JF, Oguin Iii TH, Sempowski GD, Randell SH, Heise MT, Lei YL, Boucher RC, Ting JP.
Cell Host Microbe. 2023. 31(2):243-259. PMID: 36563691
5月11日:永島
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Dominik Pfister et al., Nature, 2021 Apr;592(7854):450-456.
PMID: 33762733
4月20日:山本
Norovirus MLKL-like protein initiates cell death to induce viral egress
Guoxun Wan, Di Zhang, Robert C Orchard , Dustin C Hancks, Tiffany A Reese
Nature, 2023, 16(7955):152-158, PMID: 36991121
4月6日:小笠原
Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics.
Schwartz M, Shnayder M, Nachshon A, Arazi T, Kitsberg Y, Levi Samia R, Lavi M, Kuint R, Tsabari R, Stern-Ginossar N. Nat Microbiol. 2023, 8(3):455-468.PMID: 36732471.
3月30日:白石
Yang H, Smith RD, Sumner KP, Goodlett DR, Johnson JK, Ernst RK.
A Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Direct-from-Urine-Specimen Diagnostic for Gram-Negative Pathogens.
Microbiol Spectr. 2022. 10(6), PMID: 36255333
Yang H, Smith RD, Chandler CE, Johnson JK, Jackson SN, Woods AS, Scott AJ, Goodlett DR, Ernst RK.
Lipid A Structural Determination from a Single Colony.
Anal Chem. 2022. 94(21):7460-7465. PMID: 35576511
3月9日:谷向
Mao T, Israelow B, Peña-Hernández MA, Suberi A, Zhou L, Luyten S, Reschke M, Dong H, Homer RJ, Saltzman WM, Iwasaki A. Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses. Science. 2022 Nov 25;378(6622):eabo2523. doi: 10.1126/science.abo2523. Epub 2022 Nov 25. PMID: 36302057; PMCID: PMC9798903.
3月2日:吉田
Yannic C Bartsch, Deniz Cizmeci, Jaewon Kang, Tomer Zohar, Sivakumar Periasamy, Nickita Mehta, Jeroen Tolboom, Leslie Van der Fits, Jerry Sadoff, Christy Comeaux, Benoit Callendret, Alexander Bukreyev, Douglas A Lauffenburger, Arangassery Rosemary Bastian, Galit Alter
Antibody effector functions are associated with protection from respiratory syncytial virus
Cell. 2022, 185(26):4873-4886, PMID: 36513064
2月2日:山本
Dhiraj Acharya, Rebecca Reis, Meta Volcic, GuanQun Liu, May K Wang , Bing Shao Chia, Rayhane Nchioua, Rüdiger Groß, Jan Münch, Frank Kirchhoff, Konstantin M J Sparrer, Michaela U Gack
Actin cytoskeleton remodeling primes RIG-I-like receptor activation
Cell. 2022, 185(19):3588-3602, PMID:36113429
1月19日:福澤
Smith RD, McElheny CL, Izac JR, Gardner FM, Chandler CE, Goodlett DR, Doi Y, Johnson JK, Ernst RK. 2022.
A Novel Lipid-Based MALDI-TOF Assay for the Rapid Detection of Colistin-Resistant Enterobacter Species.
Microbiol Spectr 10:e01445-21.
1月12日: 上村
Rémi Le Guern , Teddy Grandjean , Sarah Stabler, Marvin Bauduin, Philippe Gosset , Éric Kipnis & Rodrigue Dessein
Gut colonisation with multidrug-resistant Klebsiella pneumoniae worsens Pseudomo- nas aeruginosa lung infection
Nature communications volume14, Article number: 78 (2023)
1月5日:横田
Wilson A, Fegan N, Turner MS.
Co-culture with Acinetobacter johnsonii enhances benzalkonium chloride resistance in Salmonella enterica via triggering lipid A modifications.
Int J Food Microbiol. 2022; 381:109905. doi: 10.1016/j.ijfoodmicro.2022.109905. PMID: 36095868
<2022年>
12月22日:中村
Anversa L, et al.,
Quality of dialysis water and dialysate in haemodialysis centres: Highlight for occurrence of non-fermenting gram-negative bacilli
J Appl Microbiol. 2022 132 (4):3416-3429 PMID: 35108426
12月15日: 永島
Yoshiyuki Mishima et al.,
Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10–producing regulatory B cells
J Clin Invest. 2019, 129(9): 3702–3716.
doi: 10.1172/JCI93820 PMCID: PMC6715367 PMID: 31211700
12月8日:小笠原
Slim Fourati et.al.,
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
nature immunology. 2022 Oct 31.doi: 10.1038/s41590-022-01329-5. PMID:36316476
12月1日:白石
Kevin Champagne-Jorgensen, Tamina A Jose, Andrew M Stanisz, M Firoz Mian, Alexander P Hynes, John Bienenstock.
Bacterial membrane vesicles and phages in blood after consumption of lacticaseibacillus rhamnosus JB-1.
Gut Microbes. 2021 Jan-Dec;13(1):1993583.
PMID: 34747333. DOI: 10.1080/19490976.2021.1993583.
11月24日:吉田
Joanne Haney, Swetha Vijayakrishnan, James Streetley, Kieran Dee, Daniel Max Goldfarb, Mairi Clarke, Margaret Mullin, Stephen D Carter, David Bhella, Pablo R Murcia
Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles.
Nat Microbiol. 2022. doi: 10.1038/s41564-022-01242-5. PMID: 36280786.
11月17日:上村
Amandine Nucci, Eduardo P C Rocha, Olaya Rendueles
Adaptation to novel spatially-structured environments is driven by the capsule and alters virulence-associated traits
Nat Commun. 2022 Aug 13;13(1):4751. doi: 10.1038/s41467-022-32504-9. PMID: 35963864.
11月10日:山本
Joseph D Trimarco, Sarah L Nelson, Ryan R Chaparian, Alexandra I Wells, Nathan B Murray, Parastoo Azadi, Carolyn B Coyne, Nicholas S Heaton
Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection
Nat Commun. 2022 Oct 29;13(1):6456. doi: 10.1038/s41467-022-34111-0.
10月20日:谷向
Krist Helen Antunes et al.
Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response.
Nat Commun . 2019 Jul 22;10(1):3273.
PMID: 31332169 DOI: 10.1038/s41467-019-11152-6
10月13日:横田
Jin H, Kishida K, Arase N, Matsuoka S, Nakai W, Kohyama M, Suenaga T, Yamamoto K, Sasazuki T, Arase H.
Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules.
Sci Adv. 2022; 8(9):eabj9867. doi: 10.1126/sciadv.abj9867. PMID: 35245125
9月29日:中村
Eiichi Osono, Kazumi Honda, Yuki Inoue, Kyouko Ichimura, Chisako Kamano, Toshio Akimoto, Shinya Kawamoto, Yoshihiko Norose, Shun Takaku , Rimpei Morita
Sodium Hypochlorite is Effective against Biofilms in Dialysis Equipment
Biocontrol Sci, 2021, PMID: 33716244 DOI: 10.4265/bio.26.1
9月22日: 福澤
Liao W, Cui Y, Quan J, Zhao D, Han X, Shi Q, Wang Q, Jiang Y, Du X, Li X, Yu Y. 2022.
High prevalence of colistin resistance and mcr-9/10 genes in Enterobacter spp. in a tertiary hospital over a decade.
Int J Antimicrob Agents 59(5):106573.
PMID: 35307563 DOI: 10.1016/j.ijantimicag.2022.106573
9月15日:小笠原
Nenad Bartonicek, Romain Rouet, Joanna Warren, Claudia Loetsch, Gabriela Santos Rodriguez, Stacey Walters, Francis Lin, David Zahra, James Blackburn, Jillian M Hammond, Andre L M Reis, Ira W Deveson, Nathan Zammit, Mahdi Zeraati, Shane Grey, Daniel Christ, John S Mattick, Tatyana Chtanova, Robert Brink, Marcel E Dinger, Robert J Weatheritt, Jonathan Sprent, Cecile King
The retroelement Lx9 puts a brake on the immune response to virus infection
Nature. 2022 Aug;608(7924):757-765.
PMID: 35948641 DOI: 10.1038/s41586-022-05054-9
9月8日:白石
Munhyung Bae, Chelsi D. Cassilly, Xiaoxi Liu, Sung-Moo Park, Betsabeh Khoramian Tusi, Xiangjun Chen, Jaeyoung Kwon, Pavel Filipčík, Andrew S. Bolze, Zehua Liu, Hera Vlamakis, Daniel B. Graham, Sara J. Buhrlage, Ramnik J. Xavier & Jon Clardy
Akkermansia muciniphila phospholipid induces homeostatic immune responses
Nature. 2022 Aug;608(7921):168-173.
PMID: 35896748 DOI: 10.1038/s41586-022-04985-7
9月1日:谷向
Julien Sourimant , Carolin M Lieber , Jeong-Joong Yoon , Mart Toots , Mugunthan Govindarajan , Venkata Udumula , Kaori Sakamoto , Michael G Natchus , Joseph Patti , John Vernachio , Richard K Plemper
Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymerase
Science Advances. 2022 Jun 24; 8(25):eabo2236
PMID: 35749502 PMCID: PMC9232112 DOI: 10.1126/sciadv.abo2236
8月18日:吉田
Dong Gu, Xinghai Yu, Dan Wang, Zhifei Li, Yu Zhou, Guodong Xu, Bing Yuan, Yali Qin, Mingzhou Chen
Exploring key genes and mechanisms in respiratory syncytial virus-infected BALB/c mice via multi-organ expression profiles
Front Cell Infect Microbiol. 2022 May 2;12:858305. PMID: 35586251.
8月4日:山本
S Ghosh , M Kumar , M Santiana , A Mishra , M Zhang , H Labayo, A M Chibly, H Nakamura, T Tanaka, W Henderson, E Lewis, O Voss, Y Su, Y Belkaid, J A Chiorini, M P Hoffman, N Altan-Bonnet
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7月28日:永島
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7月7日:上村
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6月30日:横田
Deng H, Zhang M, Yi C, Ge L
CCT2 is an aggrephagy receptor for clearance of solid protein aggregates.
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6月9日:福澤
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5月26日:白石
Hao H, Zhang X, Tong L, Liu Q, Liang X, Bu Y, Gong P, Liu T, Zhang L, Xia Y, Ai L, Yi H
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5月19日:中村
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5月12日：谷向
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4月28日：小笠原
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4月21日：山本
Dong Gu, Xinghai Yu, Dan Wang, Zhifei Li, Yu Zhou, Guodong Xu, Bing Yuan, Yali Qin, Mingzhou Chen
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4月7日：上村
Ruggero La Rosa, Elio Rossi, Adam M. Feist, Helle Krogh Johansen & Søren Molin
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3月24日：横田
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3月10日：谷向
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3月3日：白石
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1月27日：上村
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1月20日：小笠原
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12月2日：横田
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11月18日：小笠原
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11月11日：山本
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11月4日：福澤
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10月21日：永島
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9月16日: 谷向
Min Zheng et al.,
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9月2日:小笠原
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8月26日:永島
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8月5日: 上村
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7月8日:谷向
Li Wang , Qihui Zhu, Kunlun Xiang, Yaling Zhang, Baocun Li , Xin Yu, Guang Yang , Chungen Liang ,
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6月10日:横田
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4月15日:中村
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3月18日:横田 「alpha-Gal syndrome」
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3月11日:小笠原
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3月4日:佐藤
James K Martin, Joseph P Sheehan, Benjamin P Bratton, Gabriel M Moore, André Mateus, Sophia Hsin-Jung Li, Hahn Kim, Joshua D Rabinowitz, Athanasios Typas, Mikhail M Savitski, Maxwell Z Wilson, Zemer Gitai
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2月25日:中村
Xishao Xie, Junni Wang, Shilong Xiang, Zhimin Chen, Xiaohui Zhang, Jianghua Chen
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2月4日:永島
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1月21 日: 福澤
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Pavel P. Khil, Augusto Dulanto Chiang, Jonathan Ho, Jung-Ho Youn, Jamie K. Lemon, Juan Gea-Banacloche, Karen M. Frank, Mark Parta, Robert A. Bonomo, John P. Dekker
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12月10日：白石
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12月3日: 横田
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10月29日:福澤
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10月22日:小笠原
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10月15日: 上村
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10月8日:佐藤
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10月1日:中村
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9月24日: 福澤
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9月17日:山本
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9月10日：白石
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9月3日：上村
A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity
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8月27日：福澤
MgrB Inactivation Is Responsible for Acquired Resistance to Colistin in Enterobacter hormaechei subsp. steigerwaltii.
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8月6日：小笠原
p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus.
Menendez D, Snipe J, Marzec J, Innes CL, Polack FP, Caballero MT, Schurman SH, Kleeberger SR, Resnick MA.
J Clin Invest. 2019 Nov 1;129(11):4875-4884. doi: 10.1172/JCI128626. PMID: 31430261
7月22日：佐藤
Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae
Christoph M Ernst, Julian R Braxton, Carlos A Rodriguez-Osorio, Anna P Zagieboylo, Li Li, Alejandro Pironti , Abigail L Manson , Anil V Nair , Maura Benson, Kaelyn Cummins, Anne E Clatworthy, Ashlee M Earl, Lisa A Cosimi, Deborah T Hung
Nat Med. 2020 May;26(5):705-711. doi: 10.1038/s41591-020-0825-4. PMID: 32284589
7月15日：福澤
Colistin Heteroresistance in Enterobacter Cloacae Is Regulated by PhoPQ-dependent 4-amino-4-deoxy-l-arabinose Addition to Lipid A
Katie N Kang, Dustin R Klein, Misha I Kazi, François Guérin, Vincent Cattoir, Jennifer S Brodbelt, Joseph M Boll
Mol Microbiol., 2019, PMID: 30873646
7月1日：福澤 自粛期間中の課題の論文
Unstable Tandem Gene Amplification Generates Heteroresistance (Variation in Resistance Within a Population) to Colistin in Salmonella Enterica,
Karin Hjort, Hervé Nicoloff, Dan I Andersson
Mol Microbiol., 2016, PMID: 27381382
7月1日：横田
The length of lipoteichoic acid polymers controls Staphylococcus aureus cell size and envelope integrity.
Hesser AR, Matano LM, Vickery CR, Wood BM, Santiago AG, Morris HG, Do T, Losick R, Walker S.
J Bacteriol. 2020. doi: 10.1128/JB.00149-20. PMID: 32482719
4月9日：山本
新型コロナの論文紹介です。以下の論文に加えて、阻害薬の開発状況などまとめてみます
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S.
Cell. 2020 Mar 4. pii: S0092-8674(20)30229-4. doi: 10.1016/j.cell.2020.02.052.
4月2日：福澤
Mechanisms and clinical relevanceof bacterial heteroresistance
Andersson DI, Nicoloff H, Hjort K.
Nat Rev Microbiol. 2019 Aug;17(8):479-496. doi: 10.1038/s41579-019-0218-1. Epub 2019 Jun 24. Review.
3月26日：志賀
Staphylococcus aureus induces IL-8 expression through its lipoproteins in the human intestinal epithelial cell, Caco-2.
Kang SS, Noh SY, Park OJ, Yun CH, Han SH.
Cytokine. 2015 Sep;75(1):174-80. doi: 10.1016/j.cyto.2015.04.017. PMID: 25982554
3月12日：小笠原
An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling.
Pagliuso A, Tham TN, Allemand E, Robertin S, Dupuy B, Bertrand Q, Bécavin C, Koutero M, Najburg V, Nahori MA, Tangy F, Stavru F, Bessonov S, Dessen A, Muchardt C, Lebreton A, Komarova AV, Cossart P.
Cell Host Microbe. 2019 26(6):823-835. PMID: 31761719; PubMed Central PMCID: PMC6907008.
2月27日：佐藤
Chimeric peptidomimetic antibiotics against Gram-negative bacteria.
Luther A, Urfer M, Zahn M, Müller M, Wang SY, Mondal M, Vitale A, Hartmann JB, Sharpe T, Monte FL, Kocherla H, Cline E, Pessi G, Rath P, Modaresi SM, Chiquet P, Stiegeler S, Verbree C, Remus T, Schmitt M, Kolopp C, Westwood MA, Desjonquères N, Brabet E, Hell S, LePoupon K, Vermeulen A, Jaisson R, Rithié V, Upert G, Lederer A, Zbinden P, Wach A, Moehle K, Zerbe K, Locher HH, Bernardini F, Dale G, Eberl L, Wollscheid B, Hiller S, Robinson JA, Obrecht D.
Nature. 2019 Dec;576(7787):452-458. doi: 10.1038/s41586-019-1665-6. PMID: 31645764
1月29日：永島
Weak Agonistic LPS Restores Intestinal Immune Homeostasis.
Steimle A, Michaelis L, Di Lorenzo F, Kliem T, Münzner T, Maerz JK, Schäfer A, Lange A, Parusel R, Gronbach K, Fuchs K, Silipo A, Öz HH, Pichler BJ, Autenrieth IB, Molinaro A, Frick JS
Mol Ther. 2019 Nov 6;27(11):1974-1991. PMID:31416777. doi: 10.1016/j.ymthe.2019.07.007. Epub 2019 Jul 19.
1月16日：志賀
Lipoteichoic Acid From Lactobacillus Plantarum Inhibits Pam2CSK4-induced IL-8 Production in Human Intestinal Epithelial Cells
Noh SY, Kang S-S, Yun C-H, Han SH
Mol Immunol, 64 (1), 183-9 Mar 2015PMID: 25481370 DOI: 10.1016/j.molimm.2014.11.014
1月9日: 横田
Lactobacillus helveticus SBT2171 Induces A20 Expression via Toll-Like Receptor 2 Signaling and Inhibits the Lipopolysaccharide-Induced Activation of Nuclear Factor-kappa B and Mitogen-Activated Protein Kinases in Peritoneal Macrophages
Kawano M, Miyoshi M, Miyazaki T
Front Immunol, 10, 845 2019 Apr 17 eCollection 2019 PMID: 31057558 PMCID: PMC6478895 DOI: 10.3389/fimmu.2019.00845
<2019年>
12月19日: 福澤
Heterogeneous resistance to colistin in Enterobacter cloacae complex due to a new small transmembrane protein.
Huang L, Feng Y, Zong Z. J Antimicrob Chemother. 2019 Sep 1;74(9):2551-2558. doi: 10.1093/jac/dkz236.
12月12日：山本
Enterovirus pathogenesis requires the host methyltransferase SETD3.
Diep J, Ooi YS, Wilkinson AW, Peters CE, Foy E, Johnson JR, Zengel J, Ding S, Weng KF, Laufman O, Jang G, Xu J, Young T, Verschueren E, Kobluk KJ, Elias JE, Sarnow P, Greenberg HB, Hüttenhain R, Nagamine CM, Andino R, Krogan NJ, Gozani O, Carette JE.
Nat Microbiol. 2019 Dec;4(12):2523-2537. doi: 10.1038/s41564-019-0551-1. Epub 2019 Sep 16.
11月28日: 白石
Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth.
Shao Y, Forster SC1, Tsaliki E, Vervier K, Strang A, Simpson N, Kumar N, Stares MD, Rodger A, Brocklehurst P, Field N, Lawley TD.
Nature. 2019 Oct;574(7776):117-121. doi: 10.1038/s41586-019-1560-1. Epub 2019 Sep 18.
11月21日: 桧山
Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG.
Allonsius CN, Vandenheuvel D, Oerlemans EFM, Petrova MI, Donders GGG, Cos P, Delputte P, Lebeer S.
Sci Rep. 2019 Feb 27;9(1):2900. doi: 10.1038/s41598-019-39625-0.PMID: 30814593
10月10日: 小笠原
Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus.
Hemann EA, Green R, Turnbull JB, Langlois RA, Savan R, Gale M Jr.
Nat Immunol. 2019 Aug;20(8):1035-1045. doi: 10.1038/s41590-019-0408-z. Epub 2019 Jun 24.PMID: 31235953
10月3日: 佐藤
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ. Nature. 2017 Jun 22;546(7659):528-532. doi: 10.1038/nature22972. Epub 2017 Jun 14.PMID: 28614296
9月26日: 福澤
The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification.
Nicoloff H, Hjort K, Levin BR, Andersson DI. Nat Microbiol. 2019 Mar;4(3):504-514. doi: 10.1038/s41564-018-0342-0. Epub 2019 Feb 11.
PMID: 30742072
9月19日: 横田
Reduced Proprotein convertase subtilisin/kexin 9 (PCSK9) function increases lipoteichoic acid clearance and improves outcomes in Gram positive septic shock patients. Leung AKK, Genga KR, Topchiy E, Cirstea M, Shimada T, Fjell C, Russell JA, Boyd JH, Walley KR. Sci Rep. 2019 Jul 22;9(1):10588. doi: 10.1038/s41598-019-46745-0. PMID: 31332258
9月12日: 桧山
Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma.
Ibana JA, Sherchand SP, Fontanilla FL, Nagamatsu T, Schust DJ, Quayle AJ, Aiyar A. Sci Rep. 2018 May 31;8(1):8476. doi: 10.1038/s41598-018-26765-y. PMID: 29855501
8月22日: 山本
NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy.Princely Abudu Y, Pankiv S, Mathai BJ, Håkon Lystad A, Bindesbøll C, Brenne HB, Yoke Wui Ng M, Thiede B, Yamamoto A, Mutugi Nthiga T, Lamark T, Esguerra CV, Johansen T, Simonsen A. Dev Cell. 2019 May 20;49(4):509-525.e12. doi: 10.1016/j.devcel.2019.03.013. Epub 2019 Apr 11.PMID: 30982665
8月8日: 永島
Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis.Hayes CL, Dong J, Galipeau HJ, Jury J, McCarville J, Huang X, Wang XY, Naidoo A, Anbazhagan AN, Libertucci J, Sheridan C, Dudeja PK, Bowdish DME, Surette MG, Verdu EF. Sci Rep. 2018 Sep 21;8(1):14184. doi: 10.1038/s41598-018-32366-6.
7月25日: 白石
Campylobacter jejuni bile exposure influences outer membrane vesicles protein content and bacterial interaction with epithelial cells.
Taheri N, Mahmud AKMF, Sandblad L, Fällman M, Wai SN, Fahlgren A. Sci Rep. 2018 Nov 19;8(1):16996. doi: 10.1038/s41598-018-35409-0.
PMID:30451931
7月18日: 志賀
Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. Takagi A, Yanagi H, Ozawa H, Uemura N, Nakajima S, Inoue K, Kawai T, Ohtsu T, Koga Y. Gastroenterol Res Pract. 2016;2016:7490452. doi: 10.1155/2016/7490452. Epub 2016 Jul 11.PMID: 27478434
6月26日: 福澤
Antibiotic failure mediated by a resistant subpopulation in Enterobacter cloacae.
Band VI, Crispell EK, Napier BA, Herrera CM, Tharp GK, Vavikolanu K, Pohl J, Read TD, Bosinger SE, Trent MS, Burd EM, Weiss DS.
Nat Microbiol. 2016 May 9;1(6):16053. doi: 10.1038/nmicrobiol.2016.53.PMID: 27572838
6月19日: 小笠原
Airway response to respiratory syncytial virus has incidental antibacterial effects.
Sande CJ, Njunge JM, Mwongeli Ngoi J, Mutunga MN, Chege T, Gicheru ET, Gardiner EM, Gwela A, Green CA, Drysdale SB, Berkley JA, Nokes J, Pollard AJ. Nat Commun. 2019 May 17;10(1):2218. doi: 10.1038/s41467-019-10222-z. PMID: 31101811
5月29日: 永島
Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Cario E, Gerken G, Podolsky DK. Gastroenterology. 2007 Apr;132(4):1359-74. Epub 2007 Feb 25. DOI:10.1053/j.gastro.2007.02.056. PMID:17408640
5月23日: 佐藤
Intestinal Colonization Traits of Pandemic Multidrug-Resistant Escherichia coli ST131. Sarkar S, Hutton ML, Vagenas D, Ruter R, Schüller S, Lyras D, Schembri MA, Totsika M. J Infect Dis. 2018 Aug 14;218(6):979-990. doi: 10.1093/infdis/jiy031. PMID:29471349
5月16日: 桧山
Fur Represses Adhesion to, Invasion of, and Intracellular Bacterial Community Formation within Bladder Epithelial Cells and Motility in Uropathogenic Escherichia coli. Kurabayashi K, Agata T, Asano H, Tomita H, Hirakawa H.Infect Immun. 2016 Oct 17;84(11):3220-3231. doi: 10.1128/IAI.00369-16. Print 2016 Nov. PMID:27572332
4月18日: 山本
Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit.Corona AK, Saulsbery HM, Corona Velazquez AF, Jackson WT.Cell Rep. 2018 Mar 20;22(12):3304-3314. doi:10.1016/j.celrep.2018.03.003.
4月11日：志賀
Identification of peptides present in sour milk whey that ameliorate scopolamine-induced memory impairment in mice.
Ohsawa K, Uchida N, Ohki K, Yokogoshi H. Int J Food Sci Nutr. 2018 Feb;69(1):33-45.
doi: 10.1080/09637486.2017.1324564. Epub 2017 May 23.
3月28日：福澤
Complex Regulation Pathways of AmpC-Mediated β-Lactam Resistance in Enterobacter cloacae Complex. Guérin F, Isnard C, Cattoir V, Giard JC. Antimicrob Agents Chemother. 2015 Dec;59(12):7753-61. doi: 10.1128/AAC.01729-15. Epub 2015 Oct 5.PMID: 26438498
2月28日：永島
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K, Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D, Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B, Roberts B, Hattori M, Xavier RJ, Atarashi K, Honda K. Nature. 2019 Jan;565(7741):600-605. doi: 10.1038/s41586-019-0878-z. Epub 2019 Jan 23. PMID:30675064
2月6日：横田
Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection.
Imai T, Matsumura T, Mayer-Lambertz S, Wells CA, Ishikawa E, Butcher SK, Barnett TC, Walker MJ, Imamura A, Ishida H, Ikebe T, Miyamoto T, Ato M, Ohga S, Lepenies B, van Sorge NM, Yamasaki S.
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10662-E10671. doi: 10.1073/pnas.1809100115.
PMID: 30352847
<2018年>
12月20日:小笠原
Tropism for tuft cells determines immune promotion of norovirus pathogenesis.
Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW.
Science. 2018 Apr 13;360(6385):204-208.
PMID: 29650672
12月6日:佐藤
Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides.
Lázár V, Martins A, Spohn R, Daruka L, Grézal G, Fekete G, Számel M, Jangir PK, Kintses B, Csörgő B, Nyerges Á, Györkei Á, Kincses A, Dér A, Walter FR, Deli MA, Urbán E, Hegedűs Z, Olajos G, Méhi O, Bálint B, Nagy I, Martinek TA, Papp B, Pál C.
Nat Microbiol. 2018 Jun;3(6):718-731. doi: 10.1038/s41564-018-0164-0. Epub 2018 May 24.
PMID: 29795541
11月15日：永島
Innate Recognition of the Microbiota by TLR1 Promotes Epithelial Homeostasis and Prevents Chronic Inflammation.
Kamdar K, Johnson AMF, Chac D, Myers K, Kulur V, Truevillian K, DePaolo RW.
J Immunol. 2018 Jul 1;201(1):230-242. doi: 10.4049/jimmunol.1701216. Epub 2018 May 23.
PMID: 29794015
11月8日：山本
The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses.
Ding B, Zhang L, Li Z, Zhong Y, Tang Q, Qin Y, Chen M.
Cell Host Microbe. 2017 Apr 12;21(4):538-547.e4. doi: 10.1016/j.chom.2017.03.004.
PMID: 28407488
10月18日：横田
Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia.
Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, Suzuki S, Hegab AE, Kamata H, Tasaka S, Atarashi K, Nakamoto N, Iwata S, Honda K, Kanai T, Hasegawa N, Koyasu S, Betsuyaku T.
PLoS Pathog. 2018 Apr 5;14(4):e1006955. doi: 10.1371/journal.ppat.1006955. eCollection 2018 Apr.
PMID: 29621339
10月11日: 桧山
Targeting Deficiencies in the TLR5 Mediated Vaginal Response to Treat Female Recurrent UrinaryTract Infection.
Ali ASM, Mowbray C, Lanz M, Stanton A, Bowen S, Varley CL, Hilton P, Brown K, Robson W, Southgate J, Aldridge PD, Tyson-Capper A, Abraham S, Pickard RS, Hall J.
Sci Rep. 2017 Sep 8;7(1):11039. doi: 10.1038/s41598-017-10445-4.
PMID: 28887442
9月27日: 白石
Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.
Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW
Nature. 2018 Aug;560(7719):489-493. doi: 10.1038/s41586-018-0395-5. Epub 2018 Aug 8. Erratum in: Nature. 2018 Aug 29
PMID: 30089902
9月20日: 山本
Optimized arylomycins are a new class of Gram-negative antibiotics.
Smith PA, Koehler MFT, Girgis HS, Yan D, Chen Y, Chen Y, Crawford JJ, Durk MR, Higuchi RI, Kang J, Murray J, Paraselli P, Park S, Phung W, Quinn JG, Roberts TC, Rougé L, Schwarz JB, Skippington E, Wai J, Xu M, Yu Z, Zhang H, Tan MW, Heise CE.
Nature. 2018 Sep;561(7722):189-194. doi: 10.1038/s41586-018-0483-6. Epub 2018 Sep 12.
PMID: 30209367
9月6日: 佐藤
Comparative Genomic Analysis of Globally Dominant ST131 Clone with Other Epidemiologically Successful Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages.
Shaik S, Ranjan A, Tiwari SK, Hussain A, Nandanwar N, Kumar N, Jadhav S, Semmler T, Baddam R, Islam MA, Alam M, Wieler LH, Watanabe H, Ahmed N
MBio. 2017 Oct 24;8(5). pii: e01596-17. doi: 10.1128/mBio.01596-17.
PMID: 29066550
8月30日: 本田
Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome.
Sela U, Euler CW, Correa da Rosa J, Fischetti VA.
PLoS Pathog. 2018 Jan 11;14(1):e1006726. doi: 10.1371/journal.ppat.1006726. eCollection 2018 Jan.
PMID:29324905
8月23日: 小笠原
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.
Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE.
Nat Immunol. 2018 Apr;19(4):386-396
PMID:29556002
10.1371/journal.ppat.101005