2024

1. Yamamoto S, Ogasawara N, Sudo-Yokoyama Y, Sato S, Takata N, Yokota N, Nakano T, Hayashi K, Takasawa A, Endo M, Hinatsu M, Yoshida K, Sato T, Takahashi S, Takano K, Kojima T, Hiraki J, Yokota SI.

Bacillaceae serine proteases and Streptomyces epsilon-poly-L-lysine synergistically inactivate Caliciviridae by inhibiting RNA genome release.

Sci Rep. 2024 Jul 2;14(1):15181. doi: 10.1038/s41598-024-65963-9. PMID: 38956295

2. Yamamoto S, Ogasawara N, Mitsuhashi Y, Takano K, Yokota SI.

The clarithromycin-binding proteins NIPSNAP1 and 2 regulate cytokine production through mitochondrial quality control.

Sci Rep. 2024 Jan 29;14(1):2354. doi: 10.1038/s41598-024-52582-7. PMID: 38287119

3. Shiraishi T, Matsuzaki C, Chiou TY, Kumeta H, Kawada M, Yamamoto K, Takahashi T, Yokota SI.

Lipoteichoic acid composed of poly-glycerolphosphate containing l-lysine and involved in immunoglobulin A-inducing activity in Apilactobacillus genus.

Int J Biol Macromol. 2024 May 21; 271:132540. doi: 10.1016/j.ijbiomac.2024.132540. PMID: 38782319

4. Hiyama Y, Yamamoto S, Sato T, Ogasawara N, Masumori N, Takahashi S, Yokota SI.

Affinity of β-lactam antibiotics for Neisseria gonorrhoeae penicillin-binding protein 2 having wild, cefixime-reduced-susceptible, and cephalosporin (ceftriaxone)-resistant penA alleles.

Microb Drug Resist. 2024 Mar;30(3):141-146. doi: 10.1089/mdr.2023.0256. PMID: 38215246

5. Yamasaki-Yashiki S, Shiraishi T, Gyobu M, Sasaki H, Kunisawa J, Yokota S-i, Katakura Y.

Immunostimulatory activity of lipoteichoic acid with three fatty acid residues derived from Limosilactobacillus antri JCM 15950T.

Appl Environ Microbiol. 2024 Oct 23;90(10):e0119724. doi: 10.1128/aem.01197-24. PMID: 39240119

6. Nakamura, M., Okayama, M., Hagiwara, S., Nawa, T., Yokota, SI.

Effects of metal corrosion in the pump of a dialysis machine on the sterility of the terminal dialysate by spike-and-recovery testing with bacteria.

Ren Replace Ther. 2024 Feb 2;10:6. doi: 10.1186/s41100-024-00522-6.

7. Sato T, Uemura K, Yasuda M, Maeda A, Minamoto T, Harada K, Sugiyama M, Ikushima S, Yokota SI, Horiuchi M, Takahashi S, Asai T.

Traces of pandemic fluoroquinolone-resistant Escherichia coli clone ST131 transmitted from human society to aquatic environments and wildlife in Japan

One Health. 2024 Mar 23;18:100715. doi: 10.1016/j.onehlt.2024.100715.

8. Yamada N, Kamoshida G, Shiraishi T, Yamaguchi D, Matsuoka M, Yamauchi R, Kanda N, Kamioka R, Takemoto N, Morita Y, Fujimuro M, Yokota S-i, Yahiro K.

PmrAB, the two-component system of Acinetobacter baumannii, controls the phosphoethanolamine modification of lipooligosaccharide in response to metal ions.

J Bacteriol. 2024 May 23;206(5):e0043523. doi: 10.1128/jb.00435-23. PMID: 38661375

9. Yamamoto K, Sato T, Hao A, Asao K, Kaguchi R, Kusaka S, Ruddarraju RR, Kazamori D, Seo K, Takahashi S, Horiuchi M, Yokota SI, Lee SY, Ichikawa S.

Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target.

Nat Commun. 2024 Jun 14;15(1):5085. doi: 10.1038/s41467-024-49484-7. PMID: 38877016

○その他論文(2024年)

1. Shiraishi T, Yokota SI.

Preparation and Structural Analysis of Lipoteichoic Acid on Cell Membranes Derived from Lactic Acid Bacteria.

Methods Mol Biol. 2024;2851:39-60. doi: 10.1007/978-1-0716-4096-8_4. PMID: 39210170

2. 山本聡，小笠原徳子，三橋由佳梨，高野賢一，横田伸一．

14, 15員環マクロライド系抗菌薬の免疫調節作用とミトコンドリア代謝機能．

エンドトキシン・自然免疫研究 2024; 25: 32-36.

2023

1. Fukuzawa S, Sato T, Aoki K, Yamamoto S, Ogasawara N, Nakajima C, Suzuki Y, Horiuchi M, Takahashi S, Yokota SI.

High prevalence of colistin heteroresistance in specific species and lineages of Enterobacter cloacae complex derived from human clinical specimens.

Ann Clin Microbiol Antimicrob. 2023 Jul 15;22:60. doi: 10.1186/s12941-023-00610-1. PMID: 37454128

2. Yamamoto S, Sudo-Yokoyama Y, Ogasawara N, Yokota SI.

Rapid, simple, and cost-effective plaque assay for murine norovirus using microcrystalline cellulose.

J Virol Methods. 2023, Mar 20;316:114715. doi: 10.1016/j.jviromet.2023.114715. PMID: 36940863

3. Yokota SI, Tsukamoto N, Sato T, Ohkoshi Y, Yamamoto S, Ogasawara N.

Serotype replacement and an increase in non-encapsulated isolates among community-acquired infections of Streptococcus pneumoniae during post-vaccine era in Japan.

IJID Reg. 2023 Jul 15;8:105-110. doi: 10.1016/j.ijregi.2023.07.002. PMID: 37554357

4. Kaguchi R, Katsuyama A, Sato T, Takahashi S, Horiuchi M, Yokota SI, Ichikawa S.

Discovery of Biologically Optimized Polymyxin Derivatives Facilitated by Peptide Scanning and In Situ Screening Chemistry.

J Am Chem Soc. 2023;145(6):3665-3681. doi: 10.1021/jacs.2c12971. PMID: 36708325

5. Konno A, Okubo T, Enoeda Y, Uno T, Sato T, Yokota SI, Yano R, Yamaguchi H.

Human pathogenic bacteria on high-touch dry surfaces can be controlled by warming to human-skin temperature under moderate humidity.

PLoS One. 2023 Sep 20;18(9):e0291765. doi: 10.1371/journal.pone.0291765. PMID: 37729194

6. Nagano Y, Kuronuma K, Kitamura Y, Nagano K, Yabe H, Kudo S, Sato T, Nirasawa S, Nakae M, Horiuchi M, Yokota SI, Fujiya Y, Saito A, Takahashi S, Chiba H.

Pseudo-outbreak of Mycobacterium lentiflavum at a general hospital in Japan.

Infect Control Hosp Epidemiol. 2023 Nov;44(11):1809-1815. doi: 10.1017/ice.2023.68. PMID: 37096433

2022

1. Hiyama Y, Sato T, Takahashi S, Yamamoto S, Ogasawara N, Masumori N, Yokota SI.

Reduction of susceptibility to azoles and 5-fluorocytosine and growth acceleration in Candida albicans in glucosuria.

Diagn Microbiol Infect Dis. 2022;102(1):115556. doi: 10.1016/j.diagmicrobio.2021.115556. PMID: 34678714

2. Takumi-Tanimukai Y, Yamamoto S, Ogasawara N, Nakabayashi S, Mizuta K, Yamamoto K, Miyata R, Kakuki T, Jitsukawa S, Sato T, Tsutsumi H, Kojima T, Takano K, Yokota SI.

A hydroxypropyl methylcellulose plaque assay for human respiratory syncytial virus.

J Virol Methods. 2022;304:114528. doi: 10.1016/j.jviromet.2022.114528. PMID: 35358640t

3. Sato T, Harada K, Usui M, Yokota SI, Horiuchi M.

Colistin Susceptibility in Companion Animal-Derived Escherichia coli, Klebsiella spp., and Enterobacter spp. in Japan: Frequent Isolation of Colistin-Resistant Enterobacter cloacae Complex.

Front Cell Infect Microbiol. 2022 Jul 6;12:946841. doi: 10.3389/fcimb.2022.946841. eCollection 2022. PMID: 35873176

4. Yamamoto K, Fujiya Y, Kuronuma K, Ogasawara N, Ohkuni T, Yokota SI, Takahashi S, Takano K.

Self-reported Smell and Taste Disorders in Patients With COVID-19: A Japanese Single-center Study.

In Vivo. 2022;36(2):918-924. doi: 10.21873/invivo.12781. PMID: 35241550

5. Yokota K, Osaki T, Hayashi S, Yokota SI, Takeuchi H, Rimbara E, Ojima H, Sato T, Yonezawa H, Shibayama K, Tokunaga K, Kamiya S, Murakami K, Kato M, Sugiyama T.

Establishment of a reference panel of Helicobacter pylori strains for antimicrobial susceptibility testing.

Helicobacter. 2022;27(3):e12874. doi: 10.1111/hel.12874. PMID: 35255160

6. Matsuzaki C, Shiraishi T, Chiou TY, Nakashima Y, Higashimura Y, Yokota SI, Yamamoto K, Takahashi T.

Role of Lipoteichoic Acid from the Genus Apilactobacillus in Inducing a Strong IgA Response.

Appl Environ Microbiol. 2022;88(8):e0019022. doi: 10.1128/aem.00190-22. PMID: 35380450

7. Kojima N, Kojima S, Hosokawa S, Oda Y, Zenke D, Toura Y, Onohara E, Yokota SI, Nagaoka M, Kuroda Y.

Wall teichoic acid-dependent phagocytosis of intact cell walls of Lactiplantibacillus plantarum elicits IL-12 secretion from macrophages.

Front Microbiol. 2022;13:986396. doi: 10.3389/fmicb.2022.986396. PMID: 36016797

8. Kurumi H, Takata T, Kanda T, Sugihara T, Kakugawa T, Yokota SI, Morisaki T, Akashi T, Isomoto H.

Investigating the role of heat shock protein 47 in fibrosis in Crohn's disease.

Sci Rep. 2022 Jun 29;12(1):10966. doi: 10.1038/s41598-022-15153-2. PMID: 35768471

9. Nakaya T, Yabe M, Mashalidis EH, Sato T, Yamamoto K, Hikiji Y, Katsuyama A, Shinohara M, Minato Y, Takahashi S, Horiuchi M, Yokota S, Lee S-Y, Ichikawa S.

Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY.

Nat Commun. 2022 Dec 20;13(1):7575. doi: 10.1038/s41467-022-35227-z. PMID: 35952938

10. Takashina K, Katsuyama A, Kaguchi R, Yamamoto K, Sato T, Takahashi S, Horiuchi M, Yokota SI, Ichikawa S.

Solid-Phase Total Synthesis of Plusbacin A3.

Org Lett. 2022;24(11):2253-2257. doi: 10.1021/acs.orglett.2c00667. PMID: 35293208

11. Okamoto K, Ishikawa A, Okawa R, Yamamoto K, Sato T, Yokota SI, Chiba K, Ichikawa S.

Design, synthesis and biological evaluation of simplified analogues of MraY inhibitory natural product with rigid scaffold.

Bioorg Med Chem. 2022;55:116556. doi: 10.1016/j.bmc.2021.116556. PMID: 35016115

12. 山本圭佑，藤谷好弘，山直也，黒沼幸治，小笠原徳子，横田伸一，高橋聡，高野賢一．

COVID-19 における嗅裂閉鎖所見と嗅覚障害の検討．

日本耳鼻咽喉科免疫アレルギー感染症学会会誌 2022; 2(2): 49-54.

13. 大﨑敬子，横田憲治，林俊治，横田伸一，竹内啓晃，柴山恵吾，村鎌和成，加藤元嗣，杉山敏郎．

Helicobacter pylori薬剤感受性試験の国内標準化に向けて―耐性菌基準パネルの作成―．

日本ヘリコバクター学会誌 2022; 24(1): 44-48.

2021

1. Fukushima Y, Sato T, Tsukamoto N, Nakajima C, Suzuki Y, Takahashi S, Yokota SI.

Clonal/subclonal changes and accumulation of CTX-M-type β-lactamase genes in fluoroquinolone-resistant Escherichia coli ST131 and ST1193 strains isolated during the past 12 years, Japan.

J Glob Antimicrob Resist. 2021 Dec;27:150-155. doi: 10.1016/j.jgar.2021.08.015. PMID: 34509695

2. Sato T, Yokota SI, Tachibana T, Tamai S, Maetani S, Tamura Y, Horiuchi M.

Isolation of Human Lineage, Fluoroquinolone-Resistant and Extended-β-Lactamase-Producing Escherichia coli Isolates from Companion Animals in Japan.

Antibiotics (Basel). 2021 Nov 28;10(12):1463. doi: 10.3390/antibiotics10121463. PMID: 34943675

3. Katsuki R, Shiraishi T, Sakata S, Hirota T, Nakamura Y, Yokota SI.

Inhibitory Effect of the Glycerophosphate Moiety of Lipoteichoic Acid from Lactic Acid Bacteria on Dexamethasone-Induced Atrogin-1 Expression in C2C12 Myotubes.

J Nutr Sci Vitaminol (Tokyo). 2021;67(5):351-357. doi: 10.3177/jnsv.67.351. PMID: 34719621

4. Shiraishi T, Maeno S, Kishi S, Fujii T, Tanno H, Hirano K, Tochio T, Tanizawa Y, Arita M, Yokota S, Endo A.

Oligosaccharide Metabolism and Lipoteichoic Acid Production in Lactobacillus gasseri and Lactobacillus paragasseri.

Microorganisms. 2021; 9(8):1590. https://doi.org/10.3390/microorganisms9081590. PMID: 34442669

5. Iyama S, Tatsumi H, Shiraishi T, Yoshida M, Tatekoshi A, Endo A, Ishige T, Shiwa Y, Ibata S, Goto A, Nagashima K, Horiguchi H, Fujita C, Ikeda H, Takada K, Nobuoka T, Kamihara Y, Kikuchi S, Sato T, Ohnishi H, Yokota SI, Kobune M.

Possible clinical outcomes using early enteral nutrition in individuals with allogeneic hematopoietic stem cell transplantation: A single-center retrospective study.

Nutrition. 2020 Nov 23;83:111093. doi: 10.1016/j.nut.2020.111093. PMID: 33418488

6. Sato T, Usui M, Harada K, Fukushima Y, Nakajima C, Suzuki Y, Yokota SI.

Complete Genome Sequence of an mcr-10-Possessing Enterobacter roggenkampii Strain Isolated from a Dog in Japan.

Microbiol Resour Announc. 2021 Jul 29;10(30):e0042621. doi: 10.1128/MRA.00426-21. PMID: 34323612

7. Sato T, Usui M, Harada K, Fukushima Y, Nakajima C, Suzuki Y, Yokota SI.

Complete Genome Sequence of an mcr-9-Possessing Enterobacter asburiae Strain Isolated from a Cat in Japan.

Microbiol Resour Announc. 2021 Jul;10(26):e0028121. doi: 10.1128/MRA.00281-21. PMID: 34197197

8. Mariya T, Sato T, Fujibe Y, Ishido M, Shimada H, Kubo T, Nagai Y, Arai W, Tanaka SE, Ashikawa K, Sakuraba Y, Ishioka S, Yokota SI, Saito T.

Next-generation sequencing of 16S rRNA for identification of invasive bacterial pathogens in a formalin-fixed paraffin-embedded placental specimen: a case report of perinatal fulminant Streptococcus pyogenes infection.

Med Mol Morphol. 2021 Dec;54(4):374-379. doi: 10.1007/s00795-021-00298-2. Epub 2021 Jul 21. PMID: 34287707

2020

1. Sato T, Wada T, Nishijima S, Fukushima Y, Nakajima C, Suzuki Y, Takahashi S, Yokota S-I.

Emergence of the novel aminoglycoside acetyltransferase variant aac(6′)-Ib-D179Y and acquisition of colistin heteroresistance in carbapenem-resistant Klebsiella pneumoniae due to a disrupting mutation in the DNA repair enzyme MutS.

mBio 2020: Nov/Dec;11(6):e01954-20. doi: 10.1128/mBio.01954-20. PMID: 33443109

2. Sato T, Wada T, Shinagawa M, Fukushima Y, Nakajima C, Suzuki Y, Takahashi S, Yokota SI.

Emergence of vancomycin- and teicoplanin-resistant Enterococcus faecium via vanD5-harbouring large genomic island.

J Antimicrob Chemother. 2020 Sep 1;75(9):2411-2415. doi: 10.1093/jac/dkaa220. PMID: 32585683

3. Honda H, Sato T, Shinagawa M, Fukushima Y, Nakajima C, Suzuki Y, Kuronuma K, Takahashi S, Takahashi H, Yokota SI.

In vitro Derivation of Fluoroquinolone-resistant Mutants from Multiple Lineages of Haemophilus influenzae and Identification of Mutations Associated with Fluoroquinolone Resistance.

Antimicrob Agents Chemother. 2020 Feb;64(2):e01500-19. doi: 10.1128/AAC.01500-19. PMID: 31740553

4. Suzuki Y, Sato T, Fukushima Y, Nakajima C, Suzuki Y, Takahashi S, Yokota SI.

Contribution of β-lactamase and efflux pump overproduction to tazobactam-piperacillin resistance in clinical isolates of Escherichia coli.

Int J Antimicrob Agents. 2020 Apr;55(4):105919. doi: 10.1016/j.ijantimicag.2020.105919. Epub 2020 Feb 13. PMID: 32062000

5. Hiyama Y, Sato T, Takahashi S, Yamamoto S, Fukushima Y, Nakajima C, Suzuki Y, Yokota SI, Masumori N.

Sitafloxacin has a potent activity for eradication of extended spectrum β-lactamase-producing fluoroquinolone-resistant Escherichia coli forming intracellular bacterial communities in uroepithelial cells.

J Infect Chemother. 2020 Aug 4:S1341-321X(20)30222-1. doi: 10.1016/j.jiac.2020.07.009. Online ahead of print. PMID: 32768340

6. Ogasawara N, Poposki JA, Klingler AI, Tan BK, Hulse KE, Stevens WW, Peters AT, Grammer LC, Welch KC, Smith SS, Conley DB, Takano KI, Himi T, Kern RC, Schleimer RP, Kato A.

TNF induces production of type 2 cytokines in human group 2 innate lymphoid cells.

J Allergy Clin Immunol. 2020 Jan;145(1):437-440.e8. doi: 10.1016/j.jaci.2019.09.001. PMID: 31526804

7. Ogasawara N, Poposki JA, Klingler AI, Tan BK, Hulse KE, Stevens WW, Peters AT, Grammer LC, Welch KC, Smith SS, Conley DB, Raviv JR, Soroosh P, Takano KI, Himi T, Kern RC, Schleimer RP, Kato A.

Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps.

Mucosal Immunol. 2020 Jan;13(1):86-95. doi: 10.1038/s41385-019-0215-8. PMID: 31641233

8. Ohkoshi Y, Sato T, Murabayashi H, Sakai K, Takakuwa Y, Fukushima Y, Nakajima C, Suzuki Y, Yokota SI.

Campylobacter upsaliensis isolated from a giant hepatic cyst.

J Infect Chemother. 2020 Jul;26(7):752-755. doi: 10.1016/j.jiac.2020.02.015. PMID: 32199791

9. Terasawa Y, Sataka C, Sato T, Yamamoto K, Fukushima Y, Nakajima C, Suzuki Y, Katsuyama A, Matsumaru T, Yakushiji F, Yokota SI, Ichikawa S.

Elucidating the Structural Requirement of Uridylpeptide Antibiotics for Antibacterial Activity.

J Med Chem. 2020 Sep 10;63(17):9803-9827. doi: 10.1021/acs.jmedchem.0c00973. PMID: 32787111

10. Yamamoto K, Sato T, Hikiji Y, Katsuyama A, Matsumaru T, Yakushiji F, Yokota SI, Ichikawa S.

Synthesis and biological evaluation of a MraY selective analogue of tunicamycins.

Nucleosides Nucleotides Nucleic Acids. 2020;39(1-3):349-364. doi: 10.1080/15257770.2019.1649696. PMID: 31566068

11. Saeki M, Sato T, Furuya D, Yakuwa Y, Sato Y, Kobayashi R, Ono M, Nirasawa S, Tanaka M, Nakafuri H, Nakae M, Shinagawa M, Asanuma K, Yanagihara N, Yokota SI, Takahashi S.

Clonality investigation of clinical Escherichia coli isolates by polymerase chain reaction-based open-reading frame typing method.

J Infect Chemother. 2020 Jan;26(1):38-42. doi: 10.1016/j.jiac.2019.06.014. PMID: 31362903

12. Usui M, Maruko A, Harada M, Kawabata F, Sudo T, Noto S, Sato T, Shinagawa M, Takahashi S, Tamura Y.

Prevalence and characterization of Clostridioides difficile isolates from retail food products (vegetables and meats) in Japan.

Anaerobe. 2020 Feb;61:102132. doi: 10.1016/j.anaerobe.2019.102132. PMID: 31778810 102132

13. Munby M, Fujiki J, Aoki K, Kawaguchi C, Nakamura K, Nakamura T, Sasaki M, Sato T, Usui M, Sawa H, Yokota SI, Tamura Y, Iwano H.

Whole-genome sequence of fluoroquinolone-resistant Escherichia coli HUE1, isolated in Hokkaido, Japan.

Microbiol Resour Announc. 2020 Nov 12;9(46):e01135-20. doi: 10.1128/MRA.01135-20. PMID: 33184163

2019

1. Hiyama Y, Takahashi S, Sato T, Shinagawa M, Fukushima Y, Nakajima C, Suzuki Y, Masumori N, Yokota SI.

Evaluation of Susceptibilities to Carbapenems and Faropenem Against Cephalosporin-Resistant Neisseria gonorrhoeae Clinical Isolates with penA Mosaic Alleles.

Microb Drug Resist. 2019 Apr;25(3):427-433. doi: 10.1089/mdr.2018.0263. PMID: 30676251

2. Shiraishi T, Yamamoto S, Yokota SI.

Structural analysis of the lipoteichoic acid anchor glycolipid: Comparison of methods for degradation of the glycerophosphate backbone polymer.

J Microbiol Methods. 2019 Nov;166:105726. doi: 10.1016/j.mimet.2019.105726. PMID: 31629911

3. Kaga H, Komatsuda A, Yamamoto S, Kikuchi T, Kamata M, Sato A, Odaka M, Yokota SI, Takahashi N, Wakui H.

Comparison of measurements of anti-PLA2R antibodies in Japanese patients with membranous nephropathy using in-house and commercial ELISA.

Clin Exp Nephrol. 2019 Apr;23(4):465-473. doi: 10.1007/s10157-019-01712-x. PMID: 30756249

2018

1. Sato T, Shiraishi T, Hiyama Y, Honda H, Shinagawa M, Usui M, Kuronuma K, Masumori N, Takahashi S, Tamura Y, Yokota SI.

Contribution of novel amino acid alterations in PmrA or PmrB to colistin resistance in mcr-negative Escherichia coli clinical isolates including major multidrug-resistant lineages O25b:H4-ST131-H30Rx and non-x.

Antimicrob Agents Chemother. 2018 Jun 18. pii: AAC.00864-18. doi: 10.1128/AAC.00864-18. Print 2018 Sep. PMID: 29914952

2. Ohkoshi Y, Sato T, Wada T, Fukushima Y, Murabayashi H, Takakuwa Y, Nishiyama K, Honda H, Shiraishi T, Kuronuma K, Takahashi H, Nakajima C, Suzuki Y, Yokota SI.

Whole genome analysis of a multidrug-resistant Streptococcus pneumoniae isolate from a patient with invasive pneumococcal infection developing disseminated intravascular coagulation.

J Infect Chemother. 2018 Aug;24(8):674-681. doi: 10.1016/j.jiac.2018.01.012. Epub 2018 Feb 26.PMID:29496334

3. Sato T, Fukuda A, Usui M, Shinagawa M, Shiraishi T, Tamura Y, Takahashi S, Yokota SI.

Isolation of a mcr-1-harbouring Escherichia coli isolate from a human clinical setting in Sapporo, Japan.

J Glob Antimicrob Resist. 2018 Jun;13:20-21. doi: 10.1016/j.jgar.2018.02.010. Epub 2018 Feb 21. PMID:29476984

4. Yokota SI, Hakamada H, Yamamoto S, Sato T, Shiraishi T, Shinagawa M, Takahashi S.

Release of large amounts of lipopolysaccharides from Pseudomonas aeruginosa cells reduces their susceptibility to colistin.

Int J Antimicrob Agents. 2018 Jun;51(6):888-896. doi: 10.1016/j.ijantimicag.2018.02.004. Epub 2018 Feb 9.PMID:29432867

5. Yamamoto K, Ogasawara N, Yamamoto S, Takano K, Shiraishi T, Sato T, Tsutsumi H, Himi T, Yokota SI.

Evaluation of consistency in quantification of gene copy number by real-time reverse transcription quantitative polymerase chain reaction and virus titer by plaque-forming assay for human respiratory syncytial virus.

Microbiol Immunol. 2018 Feb;62(2):90-98. doi: 10.1111/1348-0421.12563. PMID:29266482

6. Fukuda A, Sato T, Shinagawa M, Takahashi S, Asai T, Yokota SI, Usui M, Tamura Y.

High prevalence of mcr-1, mcr-3 and mcr-5 in Escherichia coli derived from diseased pigs in Japan.

Int J Antimicrob Agents. 2018 Jan;51(1):163-164. doi: 10.1016/j.ijantimicag.2017.11.010. Epub 2017 Nov 26. PMID:29180277

7. Yamamoto S, Kuramoto K, Wang N, Situ X, Priyadarshini M, Zhang W, Cordoba-Chacon J, Layden BT, He C.

Autophagy differentially regulates insulin production and insulin sensitivity.

Cell Rep. 2018 Jun 12;23(11):3286-3299. doi: 10.1016/j.celrep.2018.05.032. PMID:29898399

8. Sato T, Harada K, Usui M, Tsuyuki Y, Shiraishi T, Tamura Y, Yokota SI.

Tigecycline Susceptibility of Klebsiella pneumoniae Complex and Escherichia coli Isolates from Companion Animals: The Prevalence of Tigecycline-Nonsusceptible K. pneumoniae Complex, Including Internationally Expanding Human Pathogenic Lineages.

Microb Drug Resist. 2018 Jul/Aug;24(6):860-867. doi: 10.1089/mdr.2017.0184. Epub 2017 Dec 12. PMID: 29232167

9. Honda H, Sato T, Shinagawa M, Fukushima Y, Nakajima C, Suzuki Y, Shiraishi T, Kuronuma K, Takahashi S, Takahashi H, Yokota SI.

Multiclonal expansion and high prevalence of β-lactamase-negative high-level ampicillin-resistant Haemophilus influenzae in Japan, and susceptibility to quinolones. Antimicrob Agents Chemother. 2018 Jul 9. pii: AAC.00851-18. doi: 10.1128/AAC.00851-18. Print 2018 Sep. PMID:29987153

10. Kuronuma K, Honda H, Mikami T, Saito A, Ikeda K, Otsuka M, Chiba H, Yamada G, Sato T, Yokota SI, Takahashi H.

Response to pneumococcal vaccine in interstitial lung disease patients: Influence of systemic immunosuppressive treatment.

Vaccine. 2018 Jul 5. pii: S0264-410X(18)30903-4. doi: 10.1016/j.Vaccine.2018.06.062. Epub 2018 Jul 6. PMID:29983256

11. Shiraishi T, Yokota S, Sato Y, Ito T, Fukiya S, Yamamoto S, Sato T, Yokota A.

Lipoteichoic acids are embedded in cell walls during logarithmic phase, but exposed on membrane vesicles in Lactobacillus gasseri JCM 1131T.

Benef Microbes. 2018 Jun 15;9(4):653-662. doi: 10.3920/BM2017.0124. Epub 2018 Apr 10. PMID: 29633638

12. Ogasawara N, Poposki JA, Klingler AI, Tan BK, Weibman AR, Hulse KE, Stevens WW, Peters AT, Grammer LC, Schleimer RP, Welch KC, Smith SS, Conley DB, Raviv JR, Soroosh P, Akbari O, Himi T, Kern RC, Kato A. IL-10, TGF-β, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells. J Allergy Clin Immunol. 2018 Mar;141(3):1147-1151. PMID:29122495

13. Ogasawara N, Klingler AI, Tan BK, Poposki JA, Hulse KE, Stevens WW, Peters AT, Grammer LC, Welch KC, Smith SS, Conley DB, Kern RC, Schleimer RP, Kato A. Epithelial activators of type 2 inflammation; elevation of TSLP, but not IL-25 or IL-33, in chronic rhinosinusitis with nasal polyps in Chicago, Illinois. Allergy. 2018 PMID:29987901

14. Nakamura H, Akashi K, Watanabe M, Ohta S, Ono J, Azuma Y, Ogasawara N, Yamamoto K, Shimizu N, Tsutsumi H, Izuhara K, Katsunuma T. Up-regulation of serum periostin and squamous cell carcinoma antigen levels in infants with acute bronchitis due to respiratory syncytial virus. Allergol Int. 2018 Apr;67(2):259-265. PMID:29122495

○その他論文(2018年)

1. 白石宗，久富亮佑，佐藤耶舞羽，森田直樹，吹谷智，佐藤豊孝，横田篤，横田伸一．Lactobacillus gasseri に共通する種特異的なリポテイコ酸の化学構造．エンドトキシン・自然免疫研究21－エンドトキシン・自然免疫研究のフロンティアをめざして－（日本エンドトキシン・自然免疫研究会編）．医学図書出版，東京，2018．pp. 35-37.

2017

1. Sato T, Suzuki Y, Shiraishi T, Honda H, Shinagawa M, Yamamoto S, Ogasawara N, Takahashi H, Takahashi S, Tamura Y, Yokota SI.

Tigecycline nonsusceptibility occurs exclusively in fluoroquinolone-resistant Escherichia coli clinical isolates, including the major multidrug-resistant lineages O25b:H4-ST131-H30R and O1-ST648.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01654-16. doi: 10.1128/AAC.01654-16. Print 2017 Feb. PMID: 27855067

2. Uemura S, Yokota SI, Shiraishi T, Kitagawa M, Hirayama S, Kyan R, Mizuno H, Sawamoto K, Inoue H, Miyamoto A, Narimatsu E.

Adaptive cross-resistance to aminoglycoside antibiotics in Pseudomonas aeruginosa induced by topical dosage of neomycin.

Chemotherapy. 2017;62(2):121-127. doi: 10.1159/000449368. Epub 2016 Oct 29. PMID: 27794569

3. Yamamoto S, Ogasawara N, Yamamoto K, Uemura C, Takaya Y, Shiraishi T, Sato T, Hashimoto S, Tsutsumi H, Takano K, Himi T, Yokota SI.

Mitochondrial proteins NIP-SNAP-1 and -2are a target for the immunomodulatory activity of clarithromycin, which involves NF-κB-mediated cytokine production.

Biochem Biophys Res Commun. 2017 Feb 12;483(3):911-916. doi: 10.1016/j.bbrc.2016.12.100. Epub 2016 Dec 18. PMID: 27998764

4. Yamamoto S, Okamoto T, Ogasawara N, Hashimoto S, Shiraishi T, Sato T, Yamamoto K,Tsutsumi H, Takano K, Himi T, Itoh H, YokotaSI.

NIP-SNAP-1 and -2 mitochondrial proteins are maintained by heat shock protein 60.

Biochem Biophys Res Commun. 2017Feb 12;483(3):917-922. doi: 10.1016/j.bbrc.2016.12.133.Epub 2016 Dec 21.PMID:28011268

5. Ohkoshi Y, Sato T, Suzuki Y, Yamamoto S, Shiraishi T, Ogasawara N, Yokota SI.

Mechanism of reduced susceptibility to fosfomycin in Escherichia coli clinical isolates.

Biomed Res Int. 2017;2017:5470241. doi: 10.1155/2017/5470241. Epub 2017 Jan 19. PMID: 28197413

6. Sato Y, Koshizuka T, Ishibashi K, Hashimoto K, Ishioka K, Ikuta K, YokotaSI, Fujii N, Suzutani T.

Involvement of herpes simplex virus type 1 UL13 protein kinase in induction of SOCS genes, the negative regulators of cytokine signaling.

Microbiol Immunol. 2017May;61(5):159-167. doi: 10.1111/1348-0421.12483. PMID:28419615

7. Sato T, Higuchi H, Yokota SI, Tamura Y.

Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA.

Microbiol Immunol. 2017 Jun;61(6):215-224. doi: 10.1111/1348-0421.12490. PMID: 28504455

8. Kitagawa M, Shiraishi T, Yamamoto S, Kutomi R, Ohkoshi Y, Sato T, Wakui H, Itoh H, Miyamoto A, Yokota SI.

Novel antimicrobial activities of a peptide derived from a Japanese soybean fermented food, Natto, against Streptococcus pneumoniae and Bacillus subtilis group strains.

AMB Express. 2017 Dec;7(1):127. doi: 10.1186/s13568-017-0430-1. Epub 2017 Jun 20.PMID: 28641406

9. Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B,Vassar R, He C, A.

Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.

PLoS Genet 2017;13(8):e1006962

10. Kaneko Y, Kohno T, Kakui T, Takano K, Ogasawara N, Miyata R,Kikuchi S, Konno T, Ohkuni T, Yajima R, Kakiuchi A, Yokota S, Himi T, Kojima T.

The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells.

Sci Rep. 2017 Sep 7;7(1):10935. doi: 10.1038/s41598-017-11481-w. PMID:83651

11. Sato T, Ohkoshi Y, Wada T, Fukushima Y, Murabayashi H, Takakuwa Y, Nishiyama K, Shiraishi T, Nakajima C, Suzuki Y, Yokota SI.

Complete genome sequence of multidrug-resistant Streptococcus pneumoniae 19F isolated from an invasive infection in Sapporo, Japan.

Genome Announc. 2017 Nov 2;5(44). pii: e01239-17. doi: 10.1128/genomeA.01239-17. PMID: 29097473

12. Kamekura R, Takano K, Yamamoto M, Kawata K, Shigehara K, Jitsukawa S, Nagaya T, Ito F, Sato A, Ogasawara N, Tsubomatsu C, Takahashi H, Nakase H, Himi T, Ichimiya S.

Cutting Edge: A critical role of lesional T follicular helper cells in the pathogenesis of IgG4-related disease.

J Immunol. 2017 Oct 15;199(8):2624-2629. doi: 10.4049/jimmunol.1601507. Epub 2017 Sep 15. PMID:28916523

13. Kojima T, Kohno T, Kubo T, Kaneko Y, Kakuki T, Kakiuchi A, Kurose M, Takano KI, Ogasawara N, Obata K, Nomura K, Miyata R, Konno T, Ichimiya S, Himi T.

Regulation of claudin-4 via p63 in human epithelial cells.

Ann N Y Acad Sci. 2017 Oct;1405(1):25-31. doi: 10.1111/nyas.13456. Epub 2017 Aug 30. Review. PMID:28856683

○その他論文(2017年)

1.白石宗，横田伸一，吹谷智，横田篤.

特集:乳酸菌が持つ新たな微生物機構の解明とその利用リポテイコ酸の構造多様性から見える乳酸菌の特徴.

JATAFFジャーナル2017; 5(3):26-32.

2.横田伸一，佐藤豊孝.

抗菌薬多剤耐性におけるefflux pumpの役割を見直す.

化学療法の領域2017; 33(8):1698-1703.

3.白石宗，北川学，山本聡，久富亮佑，佐藤豊孝，涌井秀樹，伊藤英晃，宮本篤，横田伸一.

納豆由来ペプチドの特異な殺菌効果とその作用機序.エンドトキシン・自然免疫研究 20-自然免疫における化学生物学の貢献-(日本エンドトキシン・自然免疫研究会編).

医学図書出版，東京，2017.pp.39-42.

4.山本圭佑，小笠原徳子，山本聡，堤裕幸，氷見徹夫，横田伸一.

クラリスロマイシンは気道上皮細胞でRSウイルスによって誘導されるインターフェロンの産生をIRF-3を介して調整する.

Jpn J Antibiot 2017;70(suppl. A):19-24.

5.横田伸一，山本聡，小笠原徳子，植村知加，高谷芳明，伊藤英晃，山本圭佑，白石宗，佐藤豊孝，氷見徹夫.

クラリスロマイシンの炎症反応修飾作用の分子機構の解明―気道上皮細胞のクラリスロマイシン結合タンパク質の同定と機能解明―.

Jpn J Antibiot 2017;70(suppl. A):60-64.

6.小笠原徳子, 品川雅明, 高野賢一, 坪松ちえ子, 氷見徹夫.

【臨床力UP!耳鼻咽喉科検査マニュアル】

細菌ウイルス検査抗酸菌に関する検査耳鼻咽喉科・頭頸部外科2017; 89(5):432-435.

7.白石宗，横田伸一，吹谷智，横田篤.

ミニ特集24:微生物の多様性構造情報の蓄積から見えてきたリポテイコ酸の細菌種による構造多様性.

日本乳酸菌学会誌2017;28(3):177.

8.戸板成昭，藤原伸一，高橋美智子，今野武津子，横田伸一.

家族内発症のCrohn 病3家系7症例における臨床的特徴の比較検討ならびに疾患関連遺伝子(TNFSF15)の解析.

臨牀小児医学 2017;65(1-6): 11-14.

2016

1. Hashimoto S, Yamamoto S, Ogasawara N, Sato T, Yamamoto K, Katoh H, Kubota T, Shiraishi T, Kojima T, Himi T, Tsutsumi H, Yokota S.

Mumps virus induces protein-kinase-R-dependent stress granules, partly suppressing type III interferon production.

PLoS One. 2016 Aug 25;11(8):e0161793. doi: 10.1371/journal.pone.0161793. PMID: 27560627

2. Yamamoto K, Yamamoto S, Ogasawara N, Takano K, Shiraishi T, Sato T, Miyata R, Kakuki T, Kamekura R, Kojima T, Tsutsumi H, Himi T, Yokota S.

Clarithromycin prevents human respiratory syncytial virus-induced airway epithelial responses by modulating activation of interferon regulatory factor-3.

Pharmacol Res. 2016 Sep;111:804-14. doi: 10.1016/j.phrs.2016.07.033.PMID: 27468646

3. Jinushi M, Yamamoto S, Ogasawara N, Nagano H, Hashimoto S, Tsutsumi H, Himi T, Yokota S.

Measles virus genotype D wild strains suppress interferon-stimulated gene expression more potently than laboratory strains in SiHa cells.

Viral Immunol. 2016 Jun;29(5):296-306. doi: 10.1089/vim.2016.0004.PMID: 27035543

4. Sato T, Fukuda A, Suzuki Y, Shiraishi T, Honda H, Shinagawa M, Yamamoto S, Ogasawara N, Usui M,Takahashi H, Takahashi S, Tamura Y, Yokota S.

Pathogenic lineage of mcr-negative colistin-resistant Escherichia coli, Japan, 2008-2015

Emerg Infect Dis.2016 Dec;22(12):2223-2225.doi:10.3201/eid2212.161117. PMID:27869606

5. Shiraishi T, Yokota S, Fukiya S, Yokota A.

Structural diversity and biological significance of lipoteichoic acid in Gram-positive bacteria:focusing on beneficial probiotic lactic acid bacteria.

Biosci Microbiata Food Health. 2016;35(4):147-161.Review. PMID:27867802

○その他論文(2016 年)

1. 横田伸一

抗菌薬耐性菌の驚くべき進化と脅威

日本耳鼻咽喉科感染症・エアロゾル学会会誌、2016;4(1):6-13

2. 小笠原徳子、高野賢一、氷見徹夫

微生物学的検査のピットフォール的確な感染症診断耳鼻咽喉科領域における結核菌感染症(総説)

日本耳鼻咽喉科感染症・エアロゾル学会会誌 2016;4(2):77-81

3. 白石宗、佐藤耶舞羽、横田伸一、伊藤利章、吹谷智、横田篤

Lactobacillus gasseri JCM1131T の対数期におけるリポテイコ酸の局在: Membrane vesicle 表層に露出されるリポテイコ酸

エンドトキシン・自然免疫研究19－新たなる基礎と臨床の架け橋－（日本エンドトキシン・自然免疫研究会編）．医学図書出版，東京，2016．pp. 15-17.

2015

1. Yokota S, Konno M, Fujiwara S, Toita N, Takahashi M, Yamamoto S, Ogasawara N, Shiraishi T.

Intrafamilial, preferentially mother-to-child and intraspousal, Helicobacter pylori infection in Japan determined by mutilocus sequence typing and random amplified polymorphic DNA fingerprinting.

Helicobacter. 2015 Oct;20(5):334-42. doi: 10.1111/hel.12217. Epub 2015 Feb 9.

2.Grave E, Yokota S, Yamamoto S, Tamura A, Ohtaki-Mizoguchi T, Yokota K, Oguma K, Fujiwara K, Ogawa N, Okamoto T, Otaka M, Itoh H.

Geranylgeranylacetone selectively binds to the HSP70 of Helicobacter pylori and alters its coccoid morphology.

Sci Rep. 2015 Sep 8;5:13738. doi: 10.1038/srep13738.

3.Takano K, Kaizaki A, Saikawa E, Konnno A, Ogasawara N, Himi T.

Outcomes of visually impaired patients who received cochlear implantations.

Auris Nasus Larynx. 2015 Sep 17. pii: S0385-8146(15)00199-6. doi: 10.1016/j.anl.2015.08.005.

4.Yamamoto K, Ogasawara N, Seki N, Konno N, Tsubota H, Himi T.

Vascular tumors of the external auditory canal: three case reports and a review of the literature

Springerplus. 2015 Jul 1;4:307. doi: 10.1186/s40064-015-1113-5. eCollection 2015.

5.Miyata R, Kakuki T, Nomura K, Ohkuni T, Ogasawara N, Takano K, Konno T, Kohno T, Sawada N, Himi T, Kojima T.

Poly(I:C) induced microRNA-146a regulates epithelial barrier and secretion of proinflammatory cytokines in human nasal epithelial cells.

Eur J Pharmacol. 2015 Aug 15;761:375-82. doi: 10.1016/j.ejphar.2015.04.031. Epub 2015 May 7.

6.Kamekura R, Shigehara K, Miyajima S, Jitsukawa S, Kawata K, Yamashita K, Nagaya T, Kumagai A, Sato A, Matsumiya H, Ogasawara N, Seki N, Takano K, Kokai Y, Takahashi H, Himi T, Ichimiya S.

Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma.

Clin Immunol. 2015 Jun;158(2):204-11. doi: 10.1016/j.clim.2015.02.016. Epub 2015 Mr 28.

○その他論文(2015 年)

1. 横田伸一，今野武津子.

ヘリコバクター・ピロリ感染症と鉄欠乏性貧血

臨床と微生物 2015; 42:165-170.

2. 小笠原徳子，横田伸一，山本圭祐，橋本真，堤裕幸，氷見徹夫.

最新動向から見直す呼吸器感染症マネジメントウイルス性呼吸器感染症―冬期の RS ウイルス流行に備えて.

感染と抗菌薬 2015; 18:242-246.

3. 白石宗，横田伸一，吹谷智，横田篤

腸内乳酸菌 Lactobacillus gasseri JCM 1131T のリポテイコ酸に認められた新奇構造.

エンドトキシン・自然免疫研究 18-自然免疫における生体防御ペプチドの多様性-(日本エンドトキシン研究会編).

医学図書出版，東京，2015.pp. 79-81.

4. 小笠原徳子，才川悦子，高野賢一，新谷朋子，氷見徹夫

当科における人工内耳埋め込み術の術後合併症に関する検討

Otology Japan 25(1): 51-57, 2015

2014

1.Yamamoto S, Wakui H, Kubota H, Komatsuda A, Itoh H, Yokota S.

Aminoglycosides suppress the protein folding activity of the molecular chaperone HSC70: Implication of a structure-activity relationship.

Chemotherapy. 2014;60(1):37-46. doi: 10.1159/000365880. Epub 2014 Oct 29.

2. Alvira S, Cuéllar J, Röhl A, Yamamoto S, Itoh H, Alfonso C, Rivas G, Buchner J, Valpuesta JM.

Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop.

Nat Commun. 2014 Nov 19;5:5484. doi: 10.1038/ncomms6484.

3.Sato T, Okubo T, Usui M, Yokota S, Izumiyama S, Tamura Y.

Association of veterinary third-generation cephalosporin use with the risk of emergence of extended-spectrum-cephalosporin resistance in Escherichia coli from dairy cattle in Japan. PLoS One. 2014 Apr 22;9(4):e96101. doi: 10.1371/journal.pone.0096101. eCollection 2014.

4.Okubo T, Sato T, Yokota S, Usui M, Tamura Y.

Comparison of broad-spectrum cephalosporin-resistant Escherichia coli isolated from dogs and humans in Hokkaido, Japan.

J Infect Chemother. 2014 Apr;20(4):243-9. doi: 10.1016/j.jiac.2013.12.003. Epub 2014 Jan 24

5.Kakugawa T, Yokota S, Ishimatsu Y, Hayashi T, Nakashima S, Hara S, Sakamoto N, Kubota H, Mine M, Matsuoka Y, Mukae H, Nagata K, Kohno S.

Serum heat shock protein 47 levels are elevated in acute interstitial pneumonia.

BMC Pulm Med. 2014 Mar 21;14:48. doi: 10.1186/1471-2466-14-48.

6.Sato T, Yokota S, Ichihashi R, Miyauchi T, Okubo T, Usui M, Fujii N, Tamura Y.

Isolation of Escherichia coli strains with AcrAB-TolC efflux pump-associated intermediate interpretation or resistance to fluoroquinolone, chloramphenicol and aminopenicillin from dogs admitted to a university veterinary hospital.

J Vet Med Sci. 2014 Jul;76(7):937-45. Epub 2014 Mar 18.

7.Yamamoto S, Subedi GP, Hanashima S, Satoh T, Otaka M, Wakui H, Sawada K, Yokota S, Yamaguchi Y, Kubota H, Itoh H.

ATPase activity and ATP-dependent conformational change in the co-chaperone HSP70/HSP90-organizing protein (HOP).

J Biol Chem. 2014 Apr 4;289(14):9880-6. doi: 10.1074/jbc.M114.553255. Epub 2014 Feb 17.

8.Sato T, Yokota S, Okubo T, Usui M, Fujii N, Tamura Y.

Phylogenetic association of fluoroquinolone and cephalosporin resistance of D-O1-ST648 Escherichia coli carrying blaCMY-2 from faecal samples of dogs in Japan.

J Med Microbiol. 2014 Feb;63(Pt 2):263-70. doi: 10.1099/jmm.0.054676-0. Epub 2013 Feb 21.

9.Takano K, Saikawa E, Ogasawara N, Himi T.

Cochlear implantation in a patient with Paget's disease.

Am J Otolaryngol. 2014 May-Jun;35(3):408-10. doi:10.1016/j.amjoto.2014.02.011. Epub 2014 Feb 28. PubMed PMID: 24636914.

10.Tsuji N, Fukuda K, Nagata Y, Okada H, Haga A, Hatakeyama S, Yoshida S, Okamoto T, Hosaka M, Sekine K, Ohtaka K, Yamamoto S, Otaka M, Grave E, Itoh H.

The activation mechanism of the aryl hydrocarbon receptor (AhR) by molecular chaperone HSP90.

FEBS Open Bio. 2014 Sep 16;4:796-803. doi: 10.1016/j.fob.2014.09.003. eCollection 2014.

○その他論文(2014年)

1.今野武津子，横田伸一，高橋美智子，藤原伸一，大崎敬子，神谷茂

日本人小児の最近のピロリ菌感染率と感染経路について

日本ヘリコバクター学会誌 2014: 15 (2); 68-74

2.横田伸一，堤裕幸，氷見徹夫

RS ウイルス感染症に対するマクロライドの可能性

Jpn J Antibiot. 2014: 67(3):147-155

3.氷見徹夫，高野賢一，大國毅，小笠原徳子，山本圭佑，高橋希

上気道粘膜とウイルス感染

JOHNS 2014: 30(11)1533-1539

4.氷見徹夫，高野賢一，大國毅，小笠原徳子，正木智之，小幡和史，堤裕幸，小島隆，澤田典均，横田伸一

ウイルス性炎症における上気道粘膜の役割鼻粘膜上皮機能解析から炎症制御戦略を探る

日本耳鼻咽喉科感染症・エアロゾル学会会誌 2014: 2(1) 1-5

5.小笠原徳子，横田伸一，氷見徹夫

ウイルス性呼吸器感染症　RS ウイルス・ライノウイルス

感染と抗菌薬 2014: 17(1) 68-72

6.高野賢一，大國毅，小笠原徳子，氷見徹夫

アブミ骨固着症例の検討

耳鼻咽喉科・頭頸部外科 2014: 86(2) 171-177

7.松田三千雄,山本聡,岡林環樹排膿散及湯はインターフェロン産生誘導薬か?

漢方医学 2014:38(2) 123-126

2013

1.Tsukamoto N, Ohkoshi Y, Okubo T, Sato T, Kuwahara O, Fujii N, Tamura Y, Yokota S. High prevalence of cross-resistance to aminoglycosides in fluoroquinolone-resistant Escherichia coli clinical isolates

Chemotherapy. 2013;59(5):379-84. doi: 10.1159/000361011. Epub 2014 May 13.

2.Obata K, Kojima T, Masaki T, Okabayashi T, Yokota S, Hirakawa S, Nomura K, Takasawa A, Murata M, Tanaka S, Fuchimoto J, Fujii N, Tsutsumi H, Himi T, Sawada N.

Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells.

PLoS One. 2013 Sep 18;8(9):e70225. doi: 10.1371/journal.pone.0070225.

3.Hirakawa S, Kojima T, Obata K, Okabayashi T, Yokota S, Nomura K, Obonai T, Fuchimoto J, Himi T, Tsutsumi H, Sawada N.

Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells.

J Med Virol. 2013 Dec;85(12):2141-50. doi: 10.1002/jmv.23718. Epub 2013 Sep 5.

4.Yokota S, Toita N, Yamamoto S, Fujii N, Konno M.

Positive relationship between a polymorphism in Helicobacter pylori neutrophil-activating protein a gene and iron-deficiency anemia.

Helicobacter. 2013 Apr;18(2):112-6. doi: 10.1111/hel.12011. Epub 2012 Oct 3.

5.Kojima T, Go M, Takano K, Kurose M, Ohkuni T, Koizumi J, Kamekura R, Ogasawara N, Masaki T, Fuchimoto J, Obata K, Hirakawa S, Nomura K, Keira T, Miyata R, Fujii N, Tsutsumi H, Himi T, Sawada N.

Regulation of tight junctions in upper airway epithelium.

Biomed Res Int. 2013;2013:947072. doi: 10.1155/2013/947072. Epub 2012 Dec 29.

6.Toita N, Yokota S, Fujii N, Konno M.

Clonality analysis of Helicobacter pylori in patients isolated from several biopsy specimens and gastric juice in a Japanese urban population by random amplified polymorphic DNA fingerprinting.

Gastroenterol Res Pract. 2013;2013:721306. doi: 10.1155/2013/721306. Epub 2013 Nov 17.

7.Shiraishi T, Yokota S, Morita N, Fukiya S, Tomita S, Tanaka N, Okada S, Yokota A.

Characterization of a Lactobacillus gasseri JCM 1131T lipoteichoic acid with a novel glycolipid anchor structure.

Appl Environ Microbiol. 2013 May;79(10):3315-8. doi: 10.1128/AEM.00243-13. Epub 2013 Mar 15.

8.Sato T, Yokota S, Okubo T, Ishihara K, Ueno H, Muramatsu Y, Fujii N, Tamura Y.

Contribution of the AcrAB-TolC efflux pump to high-level fluoroquinolone resistance in Escherichia coli isolated from dogs and humans.

J Vet Med Sci. 2013 May 2;75(4):407-14. Epub 2012 Nov 14.

9.Sato T, Yokota S, Uchida I, Okubo T, Usui M, Kusumoto M, Akiba M, Fujii N, Tamura Y.

Fluoroquinolone resistance mechanisms in an Escherichia coli isolate, HUE1, without quinolone resistance-determining region mutations.

Front Microbiol. 2013 May 24;4:125. doi: 10.3389/fmicb.2013.00125. eCollection 2013.

10.Kakugawa T, Yokota S, Ishimatsu Y, Hayashi T, Nakashima S, Hara S, Sakamoto N, Kubota H, Mine M, Matsuoka Y, Mukae H, Nagata K, Kohno S.

Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis.

Cell Stress Chaperones. 2013 Sep;18(5):581-90. doi: 10.1007/s12192-013-0411-5. Epub 2013 Feb 22.

11.Kakugawa T, Yokota S, Ishimatsu Y, Hayashi T, Nakashima S, Hara S, Sakamoto N, Matsuoka Y, Kubota H, Mine M, Mukae H, Nagata K, Kohno S.

Serum heat shock protein 47 levels in patients with drug-induced lung disease.

Respir Res. 2013 Nov 20;14:133. doi: 10.1186/1465-9921-14-133.

12.Fuchimoto J, Kojima T, Okabayashi T, Masaki T, Ogasawara N, Obata K, Nomura K, Hirakawa S, Kobayashi N, Shigyo T, Yokota S, Fujii N, Tsutsumi H, Himi T, Sawada N.

Humulone suppresses replication of respiratory syncytial virus and release of IL-8 and RANTES in normal human nasal epithelial cells.

Med Mol Morphol. 2013 Dec;46(4):203-9. doi: 10.1007/s00795-013-0024-1. Epub 2013 Feb 5.

○その他論文(2013年)

1.Ogasawara N, Kikuchi K, Yoshioka I, Yamashita K, Himi T.

Solitary fibrous tumor of the head and neck in a child.(Case report and review of the literature. J Pediatr Surg Case Rep 1(8) 194-196,2013)